Pakistan set West Indies a target of 456 runs to win the second Test after declaring their second innings at 227-2 on the fourth day in Abu Dhabi on Monday.
Asad Shafiq remained not out on 58 and Younis Khan on 29 as Pakistan captain Misbah-ul-Haq announced declaring the innings soon after the lunch break.
Pakistan lead the three-match series 1-0 after winning the first Test in Dubai by 56 runs.