At least two criminals were killed while two others managed to flee after exchange of fire on Thursday.
The police signaled to stop two motorcycles carrying four people at police picket near Qutabpur area of Multan.
However, the motorcyclists instead came to a halt opened fire at police which led to an encounter.
In the cross firing two criminals were killed while their cohorts managed to escape from the scene.
The bodies of criminals killed in an encounter were shifted to hospital for postmortem and the police cordoning off the area started search operation.