Prime Minister Nawaz Sharif departed for London on Sunday (today) for his medical checkup and would return to the country on May 26.
His wife Kulsoom Nawaz also accompanied him in the visit.
The premier is expected to meet influential business personalities as well.
Before the departure, PM Nawaz and Punjab Chief Minister Shehbaz Sharif held a meeting in Jati Umra.
Both discussed the ongoing Panama leaks issue and present situation of the country.
Prime Minister Nawaz earlier went to London on April 14 for medical checkup.
The visit was undertaken at a time when opposition parties had stepped up pressure on the Pakistan Muslim League-Nawaz (PML-N) government in the wake of the Panama Papers revelations.