Gaza health officials reported that an Israeli airstrike killed a pregnant woman and her 2-year-old daughter in Gaza on Sunday.
And in the West Bank, a Palestinian woman detonated an explosive in her car at a checkpoint, injuring an Israeli soldier and herself.
The attack marks the first use of explosives in the current round of violence following a series of stabbing and shooting attacks, all of which have unnerved a jittery Israel, prompting the US to issue a fresh call for restraint.
The wave of attacks -which began weeks ago in Jerusalem – have since spread to the rest of Israel, and violent protests have erupted in the West Bank and along the Gaza border, killing up to nine Palestinians over the weekend.