Flu and injury-hit Pakistan won the toss and chose to bat in the fourth and final one-day against England at Dubai Stadium here on Tuesday.
Experienced batsman Younis Khan failed to recover after missing the third match on Saturday while opener Imran Farhat was left out with a groin injury sustained during the last match.
Paceman Junaid Khan, spinner Abdul Rehman and allrounder Shoaib Malik were included in place of Farhat, Umar Gul and Aizaz Cheema.
England, who have an unassailable 3-0 lead, were also forced to leave out Ravi Bopara (sore back), Graeme Swann (calf) and resting Stuart Broad and James Anderson.
Their places were taken by Jos Butler, Jade Dernbach, Tim Bresnan and Danny Briggs.
Pakistan: Misbah-ul-Haq (capt), Shahid Afridi, Mohammad Hafeez, Shoaib Malik, Junaid Khan, Asad Shafiq, Adnan Akmal, Umar Akmal, Abdul Rehman, Saeed Ajmal, Azhar Ali
England: Alastair Cook (capt), Steven Finn, Craig Kieswetter, Eoin Morgan, Samit Patel, Kevin Pietersen, Jonathan Trott, Tim Bresnan, Danny Briggs, Jos Buttler, Jade Dernbach,
Umpires: Kumara Dharmasena (SRI) and Zameer Haider (PAK)
Tv umpire: Simon Taufel (AUS)
Match referee: Jeff Crowe (NZL)